Biological Sciences Researcher Diana Mitchell Published in Scientific Reports - Nature
April 01, 2019
Assistant Professor Diana Mitchell, Department of Biological Sciences, in collaboration with Deb Stenkamp, also of the Department of Biological Sciences, and the IBEST GRC, recently published a paper in the Scientific Reports - Nature Journal titled "Regeneration Associated Transcriptional Signature of Retinal Microglia and Macrophages." Funding for this work was provided by Idaho INBRE through a technology access grant awarded to Mitchell and a National Institutes of Health R21 grant awarded to Stenkamp. Their research seeks to understand the remarkable capacity in which zebrafish can regenerate retinal neurons, in this case with a focus on immune cell populations present during retinal repair.
This manuscript is the first work of its kind to use RNA sequencing to probe macrophage populations isolated from tissue in a regenerative state. This work has increased the knowledge of macrophage functions during zebrafish retinal regeneration and provides a wealth of candidate pathways towards understanding macrophage functions in this context.
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