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Biological Sciences Researcher Diana Mitchell Published in Scientific Reports - Nature

April 01, 2019

Assistant Professor Diana Mitchell, Department of Biological Sciences, in collaboration with Deb Stenkamp, also of the Department of Biological Sciences, and the IBEST GRC, recently published a paper in the Scientific Reports - Nature Journal titled "Regeneration Associated Transcriptional Signature of Retinal Microglia and Macrophages." Funding for this work was provided by Idaho INBRE through a technology access grant awarded to Mitchell and a National Institutes of Health R21 grant awarded to Stenkamp. Their research seeks to understand the remarkable capacity in which zebrafish can regenerate retinal neurons, in this case with a focus on immune cell populations present during retinal repair. 

This manuscript is the first work of its kind to use RNA sequencing to probe macrophage populations isolated from tissue in a regenerative state. This work has increased the knowledge of macrophage functions during zebrafish retinal regeneration and provides a wealth of candidate pathways towards understanding macrophage functions in this context.

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The University of Idaho, home of the Vandals, is Idaho’s land-grant, national research university. From its residential campus in Moscow, U of I serves the state of Idaho through educational centers in Boise, Coeur d’Alene and Idaho Falls, nine research and Extension centers, plus Extension offices in 42 counties. Home to nearly 12,000 students statewide, U of I is a leader in student-centered learning and excels at interdisciplinary research, service to businesses and communities, and in advancing diversity, citizenship and global outreach. U of I competes in the Big Sky Conference. Learn more at