U of I Researchers Find Protein Elimination by HCMV May Aid in Viral Spread Through Body
December 08, 2020
Human cytomegalovirus (HCMV) is a herpes virus that can have negative consequences in immunocompromised individuals, including babies infected during pregnancy. U of I researchers Lee Fortunato, Man I Kuan, Hannah Jaeger, Onesmo Balemba, John O’Dowd, Deborah Duricka, Emmerentia Marx and colleagues found that HCMV infection promotes the elimination of a developmentally important protein, nidogen 1. The virus can both stop the making of this protein and can induce its breakdown once it is made in cells. This elimination could prove highly beneficial to the virus when it removes nidogen 1 from the cells that line blood vessels, as it could help the virus spread more efficiently. However, elimination could result in severe developmental problems in the fetus infected during pregnancy.
About the University of Idaho
The University of Idaho, home of the Vandals, is Idaho’s land-grant, national research university. From its residential campus in Moscow, U of I serves the state of Idaho through educational centers in Boise, Coeur d’Alene and Idaho Falls, nine research and Extension centers, plus Extension offices in 42 counties. Home to nearly 11,000 students statewide, U of I is a leader in student-centered learning and excels at interdisciplinary research, service to businesses and communities, and in advancing diversity, citizenship and global outreach. U of I competes in the Big Sky and Western Athletic conferences. Learn more at uidaho.edu