C5-functionalized Pyrimide Nucleotides
OTT Case 09-026 | U.S. Patent 8,518,908 | U.S. Patent 8,912,318
Oligonucleotides exhibit high thermal affinity toward complementary single-stranded DNA, RNA and doubled-stranded DNA, along with high mismatch discrimination and significantly improved stability against nucleases. The nature of the C5-substitutent of these building blocks influences cellular uptake of the oligonucleotide and their pharmacokinetic.