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C5-functionalized Pyrimide Nucleotides

OTT Case 09-026 |  U.S. Patent 8,518,908 | U.S. Patent 8,912,318

Oligonucleotides exhibit high thermal affinity toward complementary single-stranded DNA, RNA and doubled-stranded DNA, along with high mismatch discrimination and significantly improved stability against nucleases. The nature of the C5-substitutent of these building blocks influences cellular uptake of the oligonucleotide and their pharmacokinetic.