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Readily Accessible Mimics for DNA Targeting

OTT Case 11-016 | Patent Pending

Full characterization of DNA-targeting applications with N2'-Pyrene-functionalized 2'-amino-alpha-L-LNAs has been limited by the challenging synthesis of these compounds. Researchers at the university have developed more readily accessible functional mimics. These mimics include a series of O2'-intercalator-functionalized uridine and N2'-intercalator-functionalized 2'-N-methyl-2'-aminouridine monomers. Their mimic functionality has been demonstrated via thermal denaturation, UV-visible absorption and fluorescence spectroscopy experiments.